Figures / Tables
This selection showcases figures I’ve designed for scientific publications, aiming for clarity, precision, and visual coherence. Each figure aims to translate complex data or concepts into accessible, publication-ready visuals that support and strengthen the scientific narrative.
Protein interactors of Xist lncRNA
This figure is part of an article describing a screen to identify protein interactors for Xist long non coding RNA (article available here). This work was done at the Institut Curie, in collaboration with the Heard lab, and the Taipale lab in Toronto (Donnelly Center). In females, Xist RNA is responsible for silencing one entire X chromosome (process known as X chromosome Inactivation, or XCI), and functional studies showed that specific regions of Xist are carrying specific functions, such as XCI initiation, XCI maintenance and Xist localisation. Because of this modular organisation of Xist functions, we sought to discover region-specific protein interactors using three diffrent fragments of Xist. We both confirmed previously described proteins and identified new potential Xist interactors.
Extracted and revisited from “In-cell identification and measurement of RNA-protein interactions”; Graindorge A, Pinheiro I, Nawrocka A, Mallory AC, Tsvetkov P, Gil N, Carolis C, Buchholz F, Ulitsky I, Heard E, Taipale M, Shkumatava A. Nature Communications, 2019 Nov 22;10(1):5317.
(Click on the thumbnail to enlarge the picture)
Programs used:
Graphpad Prism
Adobe Illustrator
Validation of Asteria™scRNA-seq kit
Scipio bioscience released the AsteriaTM kit in 2021, to prepare cDNA for single cells studies. In this paper presenting the kit’s main specifications, this figure shows that the operator could freeze the sample two hours following its collection, without affecting the kit’s performances in single cell type characterization.
Extracted and revisited from “RevGel-seq: instrument-free single-cell RNA sequencing using a reversible hydrogel for cell- specific barcoding”; Komatsu J, (…) Graindorge A, (…) Edelstein S. Scientific Reports, 2023 Mar 24;13(1):4866.
The article is available here.
(Click on the thumbnail to enlarge the picture)
Programs used:
Scipio Cytonaut
Adobe Illustrator
Finding co-factors of 5'UTR-bound SXL
In Drosophila melanogaster, SXL is a female-specific protein that prevent the msl2 mRNA from being translated (Msl2 expression would be lethal for the female flies). Previous studies had shown that SXL silences msl2 by binding to both its 5′ and 3’UTR, and that 5’UTR-bound SXL and 3’UTR-bound SXL have a distinct mechanism. This paper relates how we separately purified 5’UTR SXL from 3’UTR SXL to identify specific co-factors and investigate each silencing mechanism. This work has been performed in the Gebauer lab at the Center for Genomic Regulation (CRG).
Extracted and revisited from “Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW”; Graindorge A, Carré C, Gebauer F. Genes Dev., 2013 Jun 15;27(12):1421-33.
(Click on the thumbnail to enlarge the picture)
Programs used:
Adobe Photoshop
Adobe Illustrator